Himanshu Gupta, MD

What techniques or procedures do you use in your practice?

The Valley Hospital is a leader in the use of novel noninvasive approaches for diagnosing cardiac disorders including FFR-CT for coronary artery disease, comprehensive coronary phenotyping using AI algorithms, myocardial mapping using cardiac MRI, and hemodynamic echo lab for valvular and structural heart disease. I am also trained in all aspects of cardiovascular imaging including cardiovascular CT, cardiovascular MRI, echocardiography, nuclear cardiology, and stress testing.

Describe some of your professional highlights.

I am an internationally recognized expert in advanced cardiovascular imaging. I have conducted research on coronary artery disease, atherosclerosis, valvular heart disease, diastolic function, right ventricular function, pulmonary hypertension, heart failure, COVID-19, and inflammation.

What would you like patients to know about your approach to care?

With a deep understanding of the latest clinical literature and evidence, I take pride in personalizing diagnostic and treatment approaches based on a holistic view of patient care. My unique combination of clinical, diagnostic, basic research, and cutting-edge technologies enables me to address even the most challenging clinical cases. I am passionate about promoting new paradigms for clinical diagnostics and care through innovation and collaborating with a wide range of researchers and clinicians at the intersection of medicine and technology, giving mea unique perspective on patient care.

Podcast Episodes

• Seeing Your Heart Like Never Before

Valley Medical Group providers accept these insurance plans

• Hammad, A., Yeung, A., Goldschmidt, H., Gupta, H., Musat, D., Mittal, S., & Habibi, M. (2026). Compound MYH7 mutations: Risk stratification challenges in an affected family. JACC: Case Reports. https://doi.org/10.1016/j.jaccas.2026.109653
• Cramer, S.H.M., Cole, J.H., Budoff, M.J., Karlsberg, R.P., Gupta, H., Sullenberger, L.E., Rahban, H., Woods, K.M., Uzzilia, J.R., Purga, S.L., Aquino, M., Knaapen, P., Choi, A.D., & Nurmohamed, N.S. (2025). Artificial intelligence-guided coronary computed tomography angiography: Treatment recommendations versus real-world prescriptions. European Journal of Preventive Cardiology, zwaf568. https://doi.org/10.1093/eurjpc/zwaf568
• Revaiah, P.C., Tsai, T.Y., Farina, J., Ferraz-Costa, G., Jongenotter, J., Oshima, A., Garg, S., Puskas, J.D., Narula, J., Gupta, H., Agarwal, V., Tanaka, K., De Mey, J., La Meir, M., Schneider, U., Kirov, H., Saima, M., Teichgräber, U., Pompilio, G.,… Serruys, P.W. (2025). High-risk plaques in proximal and distal segments relative to graft anastomoses and non-grafted segments. Journal of Cardiovascular Computed Tomography. Advance online publication. https://doi.org/10.1016/j.jcct.2025.09.013
• Miyashita, K., Onuma, Y., Oshima, A., Tobe, A., Tsai, T.Y., Revaiah, P.C., Tu, S., Reiber, J.H.C., Andreini, D., Mushtaq, S., Pontone, G., Pompilio, G., De Mey, J., Tanaka, K., La Meir, M., Kirov, H., Doenst, T., Teichgräber, U., Narula, J., … Gupta, H.,… Serruys, P. W. (2025). Fractional flow reserve from coronary CT angiography compared with quantitative flow ratio in complex CAD. Journal of Cardiovascular Computed Tomography. Advance online publication. https://doi.org/10.1016/j.jcct.2025.09.001
• Jabagi, H., Alemany, V.S., Jones, E., Gupta, H., Kim, F., Tayal, R., Rahim, H., Burns, P., & Grau, J.B. (2025). Early TAVR explantation due to a large mobile leaflet mass and severe prosthetic valve stenosis. JACC: Case Reports, 30(18). https://doi.org/10.1016/j.jaccas.2025.103885
• Anjali, A. [Anjali], Gupta, G., Agrawal, A. [Agrawal], & Gupta, H. (2025). Evaluating diversity and stereotypes amongst AI generated representations of healthcare providers, 7. Frontiers in Digital Health. https://doi.org/10.3389/fdgth.2025.1537907
• Feuchtner, G.M., Lacaita, P.G., Bax, J.J., Rodriguez, F., Nakanishi, R., Pontone, G., Mushtaq, S., Buechel, R.R., Gräni, C., Patel, A.R., Singulane, C.C., Choi, A.D., Al-Mallah, M., Andreini, D., Karlsberg, R.P., Cho, G.W., Rochitte, C.E., Alasnag, M., Hamdan, A., … van Rosendael, A. (2025). AI-quantitative ct coronary plaque features associate with a higher relative risk in women: CONFIRM2-registry. Circulation: Cardiovascular Imaging. https://doi.org/10.1161/CIRCIMAGING.125.018235
• Aufan, M.R., Gupta, H., Sharifov, O.F., Perry, G.J., Denney Jr., T.S., & Lloyd, S.G. (2024). Non-invasively measured myocardial torsional modulus: Comparison to invasive evaluation of diastolic function. Journal of Cardiovascular Magnetic Resonance. https://doi.org/10.1016/j.jocmr.2024.101122
• Alemany, V.S., Fortier, J., Gupta, H., Zaider, A., Grau, J., Burns, P., & Jabagi, H. (2024). A rare case of IgG4-related aortitis in the thoracic aorta mimicking an intramural hematoma: Navigating the diagnostic labyrinth. Journal of Cardiothoracic Surgery, 19(1), 599. https://doi.org/10.1186/s13019-024-03026-w
• Castillero, E., Camillo, C., Erwin, W.C., Singh, S., Mohamoud, N., George, I., Eapen, E., Dockery, K., Ferrari, G., & Gupta, H. (2024). Somatostatin receptors in fibrotic myocardium. PLOS One, 19(7). https://doi.org/10.1371/journal.pone.0304813
• Narula, J., Stuckey, T.D., Nakazawa, G., Ahmadi, A., Matsumura, M., Petersen, K., Mirza, S., Ng, N., Mullen, S., Schaap, M., Leipsic, J., Rogers, C., Taylor, C.A., Yacoub, H., Gupta, H., Matsuo, H., Rinehart, S., & Maehara, A. (2024). Prospective deep learning-based quantitative assessment of coronary plaque by ct angiography compared with intravascular ultrasound. European Heart Journal. Cardiovascular Imaging, jeae115. Advance online publication. https://doi.org/10.1093/ehjci/jeae115
• Serruys, P.W., Kageyama, S., Pompilio, G., Andreini, D., Pontone, G., Mushtaq, S., La Meir, M., De Mey, J., Tanaka, K., Doenst, T., Teichgräber, U., Schneider, U., Puskas, J.D., Narula, J., Gupta, H., Agarwal, V., Leipsic, J., Masuda, S., Kotoku, N., … Onuma, Y. (2024). Coronary bypass surgery guided by computed tomography in a low-risk population. European Heart Journal. Advance online publication. https://doi.org/10.1093/eurheartj/ehae199
• van Rosendael, A.R., Crabtree, T., Bax, J.J., Nakanishi, R., Mushtaq, S., Pontone, G., Andreini, D., Buechel, R.R., Gräni, C., Feuchtner, G., Patel, T.R., Choi, A.D., Al-Mallah, M., Nabi, F., Karlsberg, R.P., Rochitte, C.E., Alasnag, M., Hamdan, A., Cademartiri, F., … CONFIRM 2 investigators (2024). Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study. Journal of Cardiovascular Computed Tomography, 18(1), 11–17. https://doi.org/10.1016/j.jcct.2023.10.004
• Girard, A.A., Denney, T.S., Gupta, H., Dell'Italia, L.J., Calhoun, D.A., Oparil, S., Sharifov, O.F., & Lloyd, S.G. (2023). Spironolactone improves left atrial function and atrioventricular coupling in patients with resistant hypertension. The International Journal of Cardiovascular Imaging. Advance online publication. https://doi.org/10.1007/s10554-023-03013-7
• Tsai, T.Y., Kageyama, S., He, X., Pompilio, G., Andreini, D., Pontone, G., La Meir, M., De Mey, J., Tanaka, K., Doenst, T., Puskas, J., Teichgräber, U., Schneider, U., Gupta, H., Leipsic, J., Garg, S., C Revaiah, P., Stanuch, M., Skalski, A.,… Serruys, P.W. (2023). Feasibility and accuracy of real-time 3D-holographic graft length measurements. European Heart Journal Digital Health, 5(1), 101–104. https://doi.org/10.1093/ehjdh/ztad071
• Nurmohamed, N.S., Cole, J.H., Budoff, M., Karlsberg, R.P., Gupta, H., Sullenberger, L.E., Quesada, C.G., Rahban, H., Woods, K.M., Uzzilia, J.R., Purga, S.L., Aquino, M., Hoffmann, U., Min, J.K., Earls, J.P., & Choi, A.D. (2024). Impact of atherosclerosis imaging-quantitative computed tomography on diagnostic certainty, downstream testing, coronary revascularization and medical therapy: The CERTAIN study. European Heart Journal Cardiovascular Imaging. Advance online publication. https://doi.org/10.1093/ehjci/jeae029
• Fortier, J.H., Thapa, Y., Crean, A.M., Gupta, H., & Grau, J.B. (2023). Invasive management of hypertrophic cardiomyopathy with clinically important obstruction: Surgical myectomy is superior, but only when accessible. The Canadian Journal of Cardiology. Advance online publication. https://doi.org/10.1016/j.cjca.2023.11.040
• Kageyama, S., Serruys, P.W., Kotoku, N., Garg, S., Ninomiya, K., Masuda, S., Morel, M., Taylor, C.A., Rogers, C., Thomsen, B., Pontone, G., Pompilio, G., Puskas, J.D., Doenst, T., La Meir, M., Teichgräber, U., Gupta, H., De Mey, J., Andreini, D., & Onuma, Y. (2023). Coronary computed tomography angiography-based SYNTAX score for comprehensive assessment of advanced coronary artery disease,
• Journal of Cardiovascular Computed Tomography. https://doi.org/10.1016/j.jcct.2023.10.012.
• Gupta, H., Spanopoulous, B., Lubat, E., Krinsky, G., Rutledge, J., Fortier, J.H., Grau, J.B., & Tayal, R. (2023). Real-world approach to comprehensive artificial intelligence-aided CT evaluation of coronary artery disease in 530 patients: A retrospective study. HELIYON, 9(9). https://doi.org/10.1016/j.heliyon.2023.e19974
• Sharifov, O.F., Denney, T.S., Jr, Girard, A.A., Gupta, H., & Lloyd, S.G. (2023). Coronary artery disease is associated with impaired atrial function regardless of left ventricular filling pressure. International Journal of Cardiology, 131102. Advance online publication. https://doi.org/10.1016/j.ijcard.2023.05.052
• Gamble, F. N., Aufan, M. R., Sharifov, O. F., Williams, L. J., Reighard, S., Calhoun, D. A., Gupta, H., Dell'Italia, L. J., Denney, T. S., Jr, & Lloyd, S. G. (2022). Diastolic function: Modeling left ventricular untwisting as a damped harmonic oscillator. Physiological Measurement, 43(2), 10.1088/1361-6579/ac4e6e.
• Aryal, S. R., Calhoun, D. A., Coffin, M. D., Dell'Italia, L. J., Denney, T. S., Jr, Gaddam, K. K., Gupta, H., Lloyd, S. G., Sharifov, O. F., Siddiqui, M., Oparil, S., & Zhang, B. (2021). 
• Spironolactone reduces aortic stiffness in patients with resistant hypertension independent of blood pressure change. Journal of the American Heart Association, 10(17).
• Al-Mubarak, M., Evanochko, W. T., Gupta, H., Lloyd, S. G., Nath, H., Prejean, S. P., Redden, D., & Singh, S. P. (2021). An updated comparison of conventional coronary angiography with cardiac magnetic resonance imaging to diagnose the origin and proximal course of anomalous coronary arteries. The Journal of invasive cardiology, 33(9), E687–E693.
• Aeron S., Agrawal A., Gupta A., & Gupta H. (2021, July). Trends in COVID-19 publications: Streamlining research using NLP and LDA. Frontiers in Digital Health. 1-24.
• Gupta H., Hoffman D.H., Joon Hong S., & Laidlaw M.S. (2021, May). Impact of Epicardial Fat on Clinical Outcomes in COVID-19. Presented at the 70th annual Scientific Sessions of the American College of Cardiology, Atlanta, GA.
• Sharifov OF, Murphy JM, Perry GJ, Tallaj J, Denney Jr. TS, Prabhu SD, Gupta H, Lloyd SG (2020). Echocardiographic diagnosis of left ventricular diastolic dysfunction: Impact of coronary artery disease. Echocardiography. 38(2): 197-206.